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Homeobox genes (HOX)

In vertebrates, the homeobox genes encoding the class of transcription factors are found in clusters named A, B, C, and D - HoxA genes on chromosome 7, HoxB genes on chromosome 17, HoxC genes on chromosome 12 and HoxD genes on chromosome 2. Each Hox gene cluster has between 9 and 11 individual genes. Homeobox genes are a group of genes that regulate development in multicellular organisms; this includes cell differentiation and morphogenesis. Some homeobox genes have been linked to congenital abnormalities and diseases.