Phosphodiesterase (PDE)

Phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. Therefore PDEs are important regulators of signal transduction mediated by these second messenger molecules. Phosphodiesterase enzymes have been shown to be different in different types of cells, including normal and leukemic lymphocytes[11] and are often targets for pharmacological inhibition due to their unique tissue distribution, structural properties, and functional properties.