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Human AMH Protein

SKU
Name
Human AMH Protein
Size
25 ug
Price
$399.00
Qty

Human AMH Protein

Description
Recombinant protein of human AMH from the target gene encoding the sequence of Arg26 - Arg560, (NM_000479), with a polyhistidine tag.
Host
CHO cells
Source
Expressed and purified from in vitro cell culture of cho-s cells with serum-free and animal derived component free condition
RefSeq Link
NM_000479; NP_000470; UniProt#: P03971; GeneID: 268;
Synonyms
MIH; MIF; MIS
Molecular Weight
60 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016].
BioActivity
It has been validated bioactive in ELISA and Chemiluminescence assays

SDS-Page Image
Fig 1 : SDS-Page Image
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