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Human KRAS G12D mutant Protein

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Human KRAS G12D mutant Protein
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Price
$398.00
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Human KRAS G12D mutant Protein

Description
Recombinant protein from the full-length sequence of homo sapiens KRAS proto-oncogene, GTPase (KRAS), G12D mutant, transcript variant b (NM_004985), with a DYKDDDDK tag.
Host
Human cells
Source
ECY203182
RefSeq Link
NM_004985; NP_004976; UniProt#: P01116; GeneID: 3845;
Synonyms
C-K-RAS; c-Ki-ras2; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS1; KRAS2; NS; NS3; RALD;
Molecular Weight
24.9 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008].

SDS-Page Image
Fig 1 : SDS-Page Image
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