×
Login

Human CLDN18.2 Protein

SKU
Name
Human CLDN18.2 Protein
Size
50 ug
Price
$398.00
Qty

Human CLDN18.2 Protein

Description
Recombinant protein from a target gene encoding the extracellular domain loop 1 of Homo sapiens claudin 18 (CLDN18), transcript variant 2 (NM_001002026), with a DYKDDDDK tag.
Host
Human cells
Source
ECY202381
RefSeq Link
NM_001002026; NP_001002026; UniProt#: P56856; GeneID: 51208;
Synonyms
SFTA5; SFTPJ; Claudin 18.2
Molecular Weight
18.6 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010].

Bioactivity
Fig. 2 : ELISA data. Immobilized IMAB362 anti-Claudin monoclonal antibody at 5 ug/mL (100ul/well), can bind human recombinant CLDN18.2 protein with a EC50 of 5~10 ug/mL, as determined by ELISA assay.
SDS-Page Image
Fig 1 : SDS-Page Image
Contact Us
View Storefront

Related Products

Customers who come to this page are also interested in the following products:


There's no citations at this moment.


There's no FAQs at this moment.


There's no reviews at this moment.