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Human SHANK3 Protein

SKU
Name
Human SHANK3 Protein
Size
50 ug
Price
$398.00
Qty

Human SHANK3 Protein

Description
Recombinant protein from the full-length sequence (Met76 - Ser1731) of homo sapiens SH3 and multiple ankyrin repeat domains 3 (SHANK3) (NM_001372044.1), with a DYKDDDDK tag.
Host
Human cells
Source
ECY201121
RefSeq Link
NM_001372044; NP_001073889; UniProt#: Q9BYB0; GeneID: 85358;
Synonyms
DEL22q13.3; PROSAP2; PSAP2; SCZD15; SPANK-2
Molecular Weight
188 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. [provided by RefSeq, Mar 2012].

SDS-Page Image
Fig 1 : SDS-Page Image
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