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Human DNASE1 Protein

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Name
Human DNASE1 Protein
Size
50 ug
Price
$398.00
Qty

Human DNASE1 Protein

Description
Recombinant protein from the secreted form (Leu23 - Lys282) of homo sapiens deoxyribonuclease 1 (DNASE1) (NM_005223), with a polyhistidine tag.
Host
Human cells
Source
ECY195771
RefSeq Link
NM_005223; NP_005214; UniProt#: P24855; GeneID: 1773;
Synonyms
DNL1; DRNI
Molecular Weight
31.3 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].

SDS-Page Image
Fig 1 : SDS-Page Image
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