|Description||Recombinant protein from the extracellular domain (Leu26-His245) of homo sapiens CD86 molecule (CD86), transcript variant 1 (NM_175862), fused with the extracellular domain (Pro134-Leu281) of homo sapiens Fas ligand (FASLG), transcript variant 1 (NM_000639) , with an human IgG1 Fc tag.|
|RefSeq Link||NM_175862; NP_787058; UniProt#: P42081; GeneID: 942;|
|Synonyms||B7-2; B7.2; B70; CD28LG2; LAB72|
|Molecular Weight||70 kDa|
|Purity||>90% by SDS-PAGE gel and Coomassie Blue staining|
|Applications||Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!|
|Formulation||Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives|
|Endotoxin||>Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)|
|Background||This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011].|
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