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Human TIM3 Protein

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Name
Human TIM3 Protein
Size
50 ug
Price
$398.00
Qty

Human TIM3 Protein

Description
Recombinant protein from the extracellular domain (Ser22 - Arg200) of homo sapiens hepatitis A virus cellular receptor 2 (HAVCR2) (NM_032782), with a polyhistidine tag.
Host
Human cells
Source
ECY114621
RefSeq Link
NM_032782; NP_116171; UniProt#: Q8TDQ0; GeneID: 84868;
Synonyms
CD366; HAVcr-2; KIM-3; Tim-3; TIM3; TIMD-3; TIMD3
Molecular Weight
21.1 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011].

SDS-Page Image
Fig 1 : SDS-Page Image
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