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Human PRPE65 Protein

SKU
Name
Human PRPE65 Protein
Size
50 ug
Price
$398.00
Qty

Human PRPE65 Protein

Description
Recombinant protein from the full-length sequence of homo sapiens RPE65, retinoid isomerohydrolase (RPE65) (NM_000329), with a Whitlow linker and DYKDDDDK tag.
Host
Human cells
Tags
DYKDDDDK
Source
ECY110821
RefSeq Link
NM_000329; NP_000320; UniProt#: Q16518; GeneID: 6121;
Synonyms
BCO3; LCA2; mRPE65; rd12; RP20; sRPE65
Molecular Weight
70 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq, Jul 2008].

SDS-Page Image
Fig 1 : SDS-Page Image
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