Human cells

DYKDDDDK

NM_033637; NP_378663; UniProt#: Q9Y297; GeneID: 8945;

BETA-TRCP; betaTrCP; bTrCP; bTrCP1; FBW1A; FBXW1; FBXW1A; FWD1

69 kDa

>90% by SDS-PAGE gel and Coomassie Blue staining

Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!

Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives

Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)

This gene encodes a member of the F-box protein familywhich is characterized by an approximately 40 amino acid motif, theF-box. The F-box proteins constitute one of the four subunits ofubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),which function in phosphorylation-dependent ubiquitination. TheF-box proteins are divided into 3 classes: Fbws containing WD-40domains, Fbls containing leucine-rich repeats, and Fbxs containingeither different protein-protein interaction modules or norecognizable motifs. The protein encoded by this gene belongs tothe Fbws class; in addition to an F-box, this protein containsmultiple WD-40 repeats. The encoded protein mediates degradation ofCD4 via its interaction with HIV-1 Vpu. It has also been shown toubiquitinate phosphorylated NFKBIA (nuclear factor of kappa lightpolypeptide gene enhancer in B-cells inhibitor, alpha), targetingit for degradation and thus activating nuclear factor kappa-B.Alternatively spliced transcript variants have been described. Arelated pseudogene exists in chromosome 6. [provided by RefSeq, Mar2012].