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Human DDX39B protein

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Name
Human DDX39B protein
Size
50 ug
Price
$398.00
Qty

Human DDX39B protein

Description
Recombinant protein from the full-length sequence of Homo sapiens DExD-box helicase 39B (DDX39B), transcript variant 2 (NM_080598), with a His tag.
Host
Human cells
Tags
His
RefSeq Link
NM_080598; NP_542165; UniProt#: Q13838; GeneID: 7919;
Synonyms
BAT1; D6S81E; UAP56
Molecular Weight
48.8 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect. [UniProtKB/Swiss-Prot Function]

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