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Human MSH5 protein

SKU
Name
Human MSH5 protein
Size
50 ug
 

Human MSH5 protein

Description
Recombinant protein from the full-length sequence of Homo sapiens mutS homolog 5 (MSH5), transcript variant 4 (NM_172166), with a His tag.
Host
Human cells
Tags
His
RefSeq Link
NM_172166; NP_751898; UniProt#: O43196; GeneID: 4439;
Synonyms
G7; MUTSH5; NG23
Molecular Weight
92.7 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]

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