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Human SMAD7 protein

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Human SMAD7 protein
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Human SMAD7 protein

Description Recombinant protein from the full-length sequence of homo sapiens SMAD family member 7 (SMAD7), transcript variant 1 (NM_005904), with a His tag.
Host Human cells
RefSeq Link NM_005904; NP_005895; UniProt#: O15105; GeneID: 4092;
Synonyms CRCS3; MADH7; MADH8
Molecular Weight 46.2 kDa
Purity >90% by SDS-PAGE gel and Coomassie Blue staining
Applications Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)
Background The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
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