×
Login

Human SMAD7 protein

SKU
Name
Human SMAD7 protein
Size
50 ug
Price
$398.00
Qty

Human SMAD7 protein

Description
Recombinant protein from the full-length sequence of homo sapiens SMAD family member 7 (SMAD7), transcript variant 1 (NM_005904), with a DYKDDDDK tag.
Host
Human cells
Tags
DYKDDDDK
RefSeq Link
NM_005904; NP_005895; UniProt#: O15105; GeneID: 4092;
Synonyms
CRCS3; MADH7; MADH8
Molecular Weight
46.2 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of TBS buffer, pH7.4, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].

Contact Us
View Storefront

Related Products


There's no citations at this moment.


There's no FAQs at this moment.


There's no reviews at this moment.