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Human ARHGEF11 protein

SKU
Name
Human ARHGEF11 protein
Size
50 ug
Price
$398.00
Qty

Human ARHGEF11 protein

Description
Recombinant protein from the full-length sequence of Homo sapiens Rho guanine nucleotide exchange factor 11 (ARHGEF11), transcript variant 2 (NM_198236), with a His tag.
Host
Human Cells
Tags
His
RefSeq Link
NM_198236; NP_937879; UniProt#: O15085; GeneID: 9826;
Synonyms
GTRAP48; PDZ-RHOGEF
Molecular Weight
172.1 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

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