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Human LEF1 protein

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Human LEF1 protein
Size
Price
$398.00
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Human LEF1 protein

Description
Recombinant protein from the full-length sequence of homo sapiens lymphoid enhancer binding factor 1 (LEF1), transcript variant 1 (NM_016269), with a His tag.
Host
Human cells
Source
RefSeq Link
NM_016269; NP_057353; UniProt#: Q9UJU2; GeneID: 51176;
Synonyms
LEF-1; TCF10; TCF1ALPHA; TCF7L3
Molecular Weight
44 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].

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