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Human FLG2 protein

SKU
Name
Human FLG2 protein
Size
50 ug
Price
$398.00
Qty

Human FLG2 protein

Description
Recombinant protein from the full-length sequence of homo sapiens filaggrin family member 2 (FLG2) (NM_001014342), with a His tag.
Host
Human cells
Source
RefSeq Link
NM_001014342; NP_001014364; UniProt#: Q5D862; GeneID: 388698;
Synonyms
IFPS; IFPS
Molecular Weight
247.9 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa. [provided by RefSeq, Dec 2015].

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