| Description | Recombinant protein from the full-length sequence of homo sapiens eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3), transcript variant 1 (NM_004836), with a His tag. |
| Host | Human cells |
| RefSeq Link | NM_004836; NP_004827; UniProt#: Q9NZJ5; GeneID: 9451; |
| Synonyms | PEK; PERK; WRS |
| Molecular Weight | 122.1 kDa |
| Purity | >90% by SDS-PAGE gel and Coomassie Blue staining |
| Applications | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Formulation | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg) |
| Background | The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015] |
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