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Human APLP2 protein

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Human APLP2 protein
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Price
$398.00
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Human APLP2 protein

Description
Recombinant protein from the full-length sequence of homo sapiens amyloid beta precursor like protein 2 (APLP2), transcript variant 3 (NM_001142277), with a His tag.
Host
Human cells
Source
RefSeq Link
NM_001142277; NP_001135749; UniProt#: Q06481; GeneID: 334;
Synonyms
APLP-2; APPH; APPL2; CDEBP
Molecular Weight
79.1 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer&apos;s disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

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