|Description||Recombinant protein from the full-length sequence of homo sapiens lectin, mannose binding 1 (LMAN1) (NM_005570), with a His tag.|
|RefSeq Link||NM_005570; NP_005561; UniProt#: P49257; GeneID: 3998;|
|Synonyms||ERGIC-53; ERGIC53; F5F8D; FMFD1; gp58; MCFD1; MR60|
|Molecular Weight||54.2 kDa|
|Purity||>90% by SDS-PAGE gel and Coomassie Blue staining|
|Applications||Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!|
|Formulation||Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives|
|Endotoxin||>Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)|
|Background||The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015]|
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