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Human SEMA4A protein

SKU
Name
Human SEMA4A protein
Size
50 ug
Price
$398.00
Qty

Human SEMA4A protein

Description
Recombinant protein from the full-length sequence of Homo sapiens semaphorin 4A (SEMA4A), transcript variant 1 (NM_022367), with a His tag.
Host
Human Cells
Tags
His
RefSeq Link
NM_022367; NP_071762; UniProt#: Q9H3S1; GeneID: 64218;
Synonyms
CORD10; RP35; SEMAB; SEMB
Molecular Weight
83.4 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010].

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