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Human CSE1L protein

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Human CSE1L protein
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Human CSE1L protein

Description Recombinant protein from the full-length sequence of homo sapiens CSE1 chromosome segregation 1-like (yeast) (CSE1L), transcript variant 1 (NM_001316), with a His tag.
Host Human cells
RefSeq Link NM_001316; NP_001307; UniProt#: P55060; GeneID: 1434;
Synonyms CAS; CSE1; XPO2
Molecular Weight 110.2 kDa
Purity >90% by SDS-PAGE gel and Coomassie Blue staining
Applications Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)
Background Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
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