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Human TARDBP protein

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Human TARDBP protein
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Human TARDBP protein

Description Recombinant protein from the full-length sequence of homo sapiens TAR DNA binding protein (TARDBP) (NM_007375), with a His tag.
Host Human cells
RefSeq Link NM_007375; NP_031401; UniProt#: Q13148; GeneID: 23435;
Synonyms ALS10; TDP-43
Molecular Weight 45 kDa
Purity >90% by SDS-PAGE gel and Coomassie Blue staining
Applications Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)
Background HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008].
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