Human PTPRR protein

Description

Recombinant protein from the full-length sequence of Homo sapiens protein tyrosine phosphatase receptor type R (PTPRR), transcript variant 2 (NM_130846), with a His tag.

Host

Human Cells

Tags

His

RefSeq Link

NM_130846; NP_570897; UniProt#: Q15256; GeneID: 5801;

Synonyms

EC-PTP; PCPTP1; PTP-SL; PTPBR7; PTPRQ

Molecular Weight

46.4 kDa

Purity

>90% by SDS-PAGE gel and Coomassie Blue staining

Applications

Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!

Formulation

Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives

Endotoxin

Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)

Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011].