Human HTRA1 protein

Description

Recombinant protein from the full-length sequence of homo sapiens HtrA serine peptidase 1 (HTRA1) (NM_002775), with a DYKDDDDK tag.

Host

Human cells

Tags

DYKDDDDK

RefSeq Link

NM_002775; NP_002766; UniProt#: Q92743; GeneID: 5654;

Synonyms

ARMD7; CADASIL2; CARASIL; HtrA; L56; ORF480; PRSS11

Molecular Weight

51.3 kDa

Purity

>90% by SDS-PAGE gel and Coomassie Blue staining

Applications

Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!

Formulation

Purified protein formulated in a sterile solution of TBS buffer, pH7.4, without any preservatives

Endotoxin

Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)

Background

This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008].