×
Login

Human UGT1A1 protein

SKU
Name
Human UGT1A1 protein
Size
50 ug
Price
$398.00
Qty

Human UGT1A1 protein

Description
Recombinant protein from the full-length sequence of homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) (NM_000463), with a His tag.
Host
Human cells
Source
RefSeq Link
NM_000463; NP_000454; UniProt#: P22309; GeneID: 54658;
Synonyms
BILIQTL1; GNT1; HUG-BR1; UDPGT; UDPGT 1-1; UGT1; UGT1A
Molecular Weight
57.1 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5&apos; exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008]

Contact Us
View Storefront

Related Products


There's no citations at this moment.


There's no FAQs at this moment.


There's no reviews at this moment.