Human FTO protein

Human FTO protein

Human FTO protein

Description Recombinant protein from the full-length sequence of homo sapiens FTO, alpha-ketoglutarate dependent dioxygenase (FTO) (NM_001080432), with a His tag.
Host Human cells
RefSeq Link NM_001080432; NP_001073901; UniProt#: Q9C0B1; GeneID: 79068;
Synonyms ALKBH9; BMIQ14; GDFD
Molecular Weight 58.1 kDa
Purity >90% by SDS-PAGE gel and Coomassie Blue staining
Applications Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)
Background This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011].
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