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Human HLA-DMB protein

SKU
Name
Human HLA-DMB protein
Size
50 ug
Price
$398.00
Qty

Human HLA-DMB protein

Description
Recombinant protein from the full-length sequence of homo sapiens major histocompatibility complex, class II, DM beta (HLA-DMB-DMB) (NM_002118), with a His tag.
Host
Human Cells
Tags
His
RefSeq Link
NM_002118; NP_002109; UniProt#: P28068; GeneID: 3109;
Synonyms
D6S221E; RING7
Molecular Weight
27.1 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

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