Human KEAP1 protein

Description

Recombinant protein from the full-length sequence of homo sapiens kelch like ECH associated protein 1 (KEAP1), transcript variant 1 (NM_203500), with a DYKDDDDK tag.

Host

Human cells

Tags

DYKDDDDK

RefSeq Link

NM_203500; NP_987096; UniProt#: Q14145; GeneID: 9817;

Synonyms

INrf2; KLHL19

Molecular Weight

69.5 kDa

Purity

>90% by SDS-PAGE gel and Coomassie Blue staining

Applications

Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!

Formulation

Purified protein formulated in a sterile solution of TBS buffer, pH7.4, without any preservatives

Endotoxin

Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)

Background

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008].