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Human NUMB protein

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Name
Human NUMB protein
Size
50 ug
Price
$398.00
Qty

Human NUMB protein

Description
Recombinant protein from the full-length sequence of homo sapiens numb homolog (Drosophila) (NUMB), transcript variant 1 (NM_001005743), with a His tag.
Host
Human cells
Source
RefSeq Link
NM_001005743; NP_001005743; UniProt#: P49757; GeneID: 8650;
Synonyms
C14orf41; c14_5527; S171
Molecular Weight
70.6 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. [UniProtKB/Swiss-Prot Function]

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