×
Login

Human PDCD6IP protein

SKU
Name
Human PDCD6IP protein
Size
50 ug
Price
$398.00
Qty

Human PDCD6IP protein

Description
Recombinant protein from the full-length sequence of Homo sapiens programmed cell death 6 interacting protein (PDCD6IP), transcript variant 1 (NM_013374), with a His tag.
Host
Human Cells
Tags
His
RefSeq Link
NM_013374; NP_037506; UniProt#: Q8WUM4; GeneID: 10015;
Synonyms
AIP1; ALIX; DRIP4; HP95
Molecular Weight
95.8 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012].

Contact Us
View Storefront

Related Products


There's no citations at this moment.


There's no FAQs at this moment.


There's no reviews at this moment.