| Description | Recombinant protein from the full-length sequence of homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 4 (ADAMTS4) (NM_005099), with a His tag. |
| Host | Human cells |
| RefSeq Link | NM_005099; NP_005090; UniProt#: O75173; GeneID: 9507; |
| Synonyms | ADAMTS-2; ADAMTS-4; ADMP-1 |
| Molecular Weight | 90 kDa |
| Purity | >90% by SDS-PAGE gel and Coomassie Blue staining |
| Applications | Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only! |
| Formulation | Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives |
| Endotoxin | >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg) |
| Background | Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site. [UniProtKB/Swiss-Prot Function] |
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