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Human CTTN protein

SKU
Name
Human CTTN protein
Size
50 ug
Price
$398.00
Qty

Human CTTN protein

Description
Recombinant protein from the full-length sequence of homo sapiens cortactin (CTTN), transcript variant 2 (NM_138565), with a His tag.
Host
Human cells
Tags
His
RefSeq Link
NM_138565; NP_612632; UniProt#: Q14247; GeneID: 2017;
Synonyms
EMS1
Molecular Weight
57.3 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010].

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