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Human TIA1 protein

SKU
Name
Human TIA1 protein
Size
50 ug
Price
$398.00
Qty

Human TIA1 protein

Description
Recombinant protein from the full-length sequence of homo sapiens TIA1 cytotoxic granule associated RNA binding protein (TIA1), transcript variant 2 (NM_022173), with a His tag.
Host
Human cells
Source
RefSeq Link
NM_022173; NP_071505; UniProt#: P31483; GeneID: 7072;
Synonyms
TIA-1; WDM
Molecular Weight
42.8 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq, Jul 2008].

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