Human CLP1 protein

Human CLP1 protein

Human CLP1 protein

Description Recombinant protein from the full-length sequence of homo sapiens cleavage and polyadenylation factor I subunit 1 (CLP1), transcript variant 1 (NM_006831), with a His tag.
Host Human cells
RefSeq Link NM_006831; NP_006822; UniProt#: Q92989; GeneID: 10978;
Synonyms hClp1; HEAB
Molecular Weight 47.5 kDa
Purity >90% by SDS-PAGE gel and Coomassie Blue staining
Applications Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)
Background This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
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