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Human IKZF3 protein

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Human IKZF3 protein
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Human IKZF3 protein

Description Recombinant protein from the full-length sequence of homo sapiens IKAROS family zinc finger 3 (IKZF3), transcript variant 1 (NM_012481), with a His tag.
Host Human cells
RefSeq Link NM_012481; NP_036613; UniProt#: Q9UKT9; GeneID: 22806;
Synonyms AIO; AIOLOS; ZNFN1A3
Molecular Weight 57.8 kDa
Purity >90% by SDS-PAGE gel and Coomassie Blue staining
Applications Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)
Background This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]
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