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Human SH2B3 protein

SKU
Name
Human SH2B3 protein
Size
50 ug
Price
$398.00
Qty

Human SH2B3 protein

Description
Recombinant protein from the full-length sequence of homo sapiens SH2B adaptor protein 3 (SH2B3), transcript variant 1 (NM_005475), with a His tag.
Host
Human cells
Tags
His
RefSeq Link
NM_005475; NP_005466; UniProt#: Q9UQQ2; GeneID: 10019;
Synonyms
IDDM20; LNK
Molecular Weight
63 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014].

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