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Human PLOD2 protein

SKU
Name
Human PLOD2 protein
Size
50 ug
Price
$398.00
Qty

Human PLOD2 protein

Description
Recombinant protein from the full-length sequence of homo sapiens procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2), transcript variant 1 (NM_182943), with a DYKDDDDK tag.
Host
Human cells
Tags
DYKDDDDK
RefSeq Link
NM_182943; NP_891988; UniProt#: O00469; GeneID: 5352;
Synonyms
BRKS2; LH2; TLH
Molecular Weight
84.4 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of TBS buffer, pH7.4, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

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