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Human POU5F1 protein

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Name
Human POU5F1 protein
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Price
$398.00
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Human POU5F1 protein

Description
Recombinant protein from the full-length sequence of homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 1 (NM_002701), with a His tag.
Host
Human cells
Source
RefSeq Link
NM_002701; NP_002692; UniProt#: Q01860; GeneID: 5460;
Synonyms
Oct-3; Oct-4; OCT3; OCT4; OTF-3; OTF3; OTF4
Molecular Weight
38.4 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing&apos;s sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]

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