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Human CUL5 protein

SKU
Name
Human CUL5 protein
Size
50 ug
Price
$398.00
Qty

Human CUL5 protein

Description
Recombinant protein from the full-length sequence of Homo sapiens cullin 5 (CUL5) (NM_003478), with a His tag.
Host
Human Cells
Tags
His
RefSeq Link
NM_003478; NP_003469; UniProt#: Q93034; GeneID: 8065;
Synonyms
VACM-1; VACM1
Molecular Weight
90.8 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor. [UniProtKB/Swiss-Prot Function]

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