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Human SHC1 protein

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Human SHC1 protein
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Price
$398.00
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Human SHC1 protein

Description
Recombinant protein from the full-length sequence of homo sapiens SHC adaptor protein 1 (SHC1), transcript variant 2 (NM_003029), with a His tag.
Host
Human cells
Source
RefSeq Link
NM_003029; NP_003020; UniProt#: P29353; GeneID: 6464;
Synonyms
SHC; SHCA
Molecular Weight
51.5 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].

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