Human AXL protein

Description

Recombinant protein from the full-length sequence of homo sapiens AXL receptor tyrosine kinase (AXL), transcript variant 1 (NM_021913), with a DYKDDDDK tag.

Host

Human cells

Tags

DYKDDDDK

RefSeq Link

NM_021913; NP_068713; UniProt#: P30530; GeneID: 558;

Synonyms

ARK; JTK11; Tyro7; UFO

Molecular Weight

98.2 kDa

Purity

>90% by SDS-PAGE gel and Coomassie Blue staining

Applications

Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!

Formulation

Purified protein formulated in a sterile solution of TBS buffer, pH7.4, without any preservatives

Endotoxin

Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)

Background

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]