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Human PTPRN2 protein

SKU
Name
Human PTPRN2 protein
Size
50 ug
 

Human PTPRN2 protein

Description
Recombinant protein from the full-length sequence of Homo sapiens protein tyrosine phosphatase receptor type N2 (PTPRN2), transcript variant 2 (NM_130842), with a DYKDDDDK tag.
Host
Human Cells
Tags
DYKDDDDK
RefSeq Link
NM_130842; NP_570857; UniProt#: Q92932; GeneID: 5799;
Synonyms
IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2
Molecular Weight
109.4 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of TBS buffer, pH7.4, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

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