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Human BRAF protein

SKU
Name
Human BRAF protein
Size
50 ug
Price
$398.00
Qty

Human BRAF protein

Description
Recombinant protein from the full-length sequence of homo sapiens B-Raf proto-oncogene, serine/threonine kinase (BRAF) (NM_004333), with a His tag.
Host
Human cells
Tags
His
RefSeq Link
NM_004333; NP_004324; UniProt#: P15056; GeneID: 673;
Synonyms
B-raf; B-RAF1; BRAF1; NS7; RAFB1
Molecular Weight
84 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008].

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