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Human NR1I2 protein

SKU
Name
Human NR1I2 protein
Size
50 ug
Price
$398.00
Qty

Human NR1I2 protein

Description
Recombinant protein from the full-length sequence of homo sapiens nuclear receptor subfamily 1 group I member 2 (NR1I2), transcript variant 1 (NM_003889), with a DYKDDDDK tag.
Host
Human cells
Tags
DYKDDDDK
RefSeq Link
NM_003889; NP_003880; UniProt#: O75469; GeneID: 8856;
Synonyms
BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR
Molecular Weight
49.6 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of TBS buffer, pH7.4, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]

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