Human cells

DYKDDDDK

NM_003679; NP_003670; UniProt#: O15229; GeneID: 8564;

dJ317G22.1

55.6 kDa

>90% by SDS-PAGE gel and Coomassie Blue staining

Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!

Purified protein formulated in a sterile solution of TBS buffer, pH7.4, without any preservatives

Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. [UniProtKB/Swiss-Prot Function]