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Human KMO protein

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Human KMO protein
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Human KMO protein

Description Recombinant protein from the full-length sequence of homo sapiens kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (KMO) (NM_003679), with a His tag.
Host Human cells
RefSeq Link NM_003679; NP_003670; UniProt#: O15229; GeneID: 8564;
Synonyms dJ317G22.1
Molecular Weight 55.6 kDa
Purity >90% by SDS-PAGE gel and Coomassie Blue staining
Applications Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin >Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)
Background Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. [UniProtKB/Swiss-Prot Function]
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