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Human EIF4G1 protein

SKU
Name
Human EIF4G1 protein
Size
50 ug
Price
$398.00
Qty

Human EIF4G1 protein

Description
Recombinant protein from the full-length sequence of homo sapiens eukaryotic translation initiation factor 4 gamma 1 (EIF4G1), transcript variant 5 (NM_004953), with a DYKDDDDK tag.
Host
Human cells
Tags
DYKDDDDK
RefSeq Link
NM_004953; NP_004944; UniProt#: G5E9S1; GeneID: 1981;
Synonyms
EIF-4G1; EIF4F; EIF4G; EIF4GI; P220; PARK18
Molecular Weight
154.6 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of TBS buffer, pH7.4, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010].

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