|Description||Recombinant protein from the full-length sequence of homo sapiens prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (PTGS1), transcript variant 1 (NM_000962), with a His tag.|
|RefSeq Link||NM_000962; NP_000953; UniProt#: P23219; GeneID: 5742;|
|Synonyms||COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS|
|Molecular Weight||65.9 kDa|
|Purity||>90% by SDS-PAGE gel and Coomassie Blue staining|
|Applications||Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!|
|Formulation||Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives|
|Endotoxin||>Endotoxin level is < 0.1 ng/µg of protein (<1EU/µg)|
|Background||Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. [UniProtKB/Swiss-Prot Function]|
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