Human PTEN protein
Recombinant protein from the full-length sequence of homo sapiens phosphatase and tensin homolog (PTEN), transcript variant 1 (NM_000314), with a DYKDDDDK tag.
10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
>90% by SDS-PAGE gel and Coomassie Blue staining
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Purified protein formulated in a sterile solution of TBS buffer, pH7.4, without any preservatives
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Isoform alpha: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. [UniProtKB/Swiss-Prot Function]
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