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Human MSH6 protein

SKU
Name
Human MSH6 protein
Size
50 ug
Price
$398.00
Qty

Human MSH6 protein

Description
Recombinant protein from the full-length sequence of homo sapiens mutS homolog 6 (MSH6), transcript variant 1 (NM_000179), with a His tag.
Host
Human cells
Source
RefSeq Link
NM_000179; NP_000170; UniProt#: P52701; GeneID: 2956;
Synonyms
GTBP; GTMBP; HNPCC5; HSAP; p160
Molecular Weight
152.6 kDa
Purity
>90% by SDS-PAGE gel and Coomassie Blue staining
Applications
Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Formulation
Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives
Endotoxin
Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Background
This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013].

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